The Science Behind WIZBE
Rigorous research, premium ingredients, and a commitment to cognitive excellence.
Introducing the Most Bioavailable Magniferin in the World
Mango leaf extract's active compound, magniferin, has demonstrated remarkable cognitive benefits in clinical and preclinical studies. However, its potential was long hampered by poor water solubility, resulting in low bioavailability. This limitation posed a significant challenge for its effective use in supplements.
In March 2024, Nektium Pharma achieved a breakthrough by introducing Zynamite® S, a water-soluble formulation of mango leaf extract that revolutionizes magniferin delivery.
Inspired by this groundbreaking development, we embarked on creating a next-generation nootropic supplement. By leveraging the enhanced bioavailability of Zynamite® S, our goal is to harness the full cognitive potential of magniferin, offering a more effective, portable, safe and scientifically-backed nootropic solution.
Data adapted from Ref. 10
How Zynamite Works
Zynamite is a patented, scientifically validated extract from mango leaves (Mangifera indica) that naturally enhances cognitive performance through multiple mechanisms of action.
Neurotransmitter Modulation
Acts synergistically with caffeine to enhance dopamine and norepinephrine activity in the central nervous system, improving attention, alertness, and mental processing speed.
Neuroprotection
Provides therapeutic potential for managing cognitive decline in neuropsychiatric and neurodegenerative disorders through antioxidant and anti-inflammatory properties.
Rapid Onset & Duration
Clinical studies show noticeable cognitive improvements within 30-60 minutes of consumption, with sustained effects lasting at least 4-6 hours.
Clinical Evidence & Research
Acute Cognitive Effects: A double-blind, placebo-controlled crossover study demonstrated that a polyphenol-rich leaf extract of Mangifera indica L. (Zynamite) significantly improved cognitive function in healthy adults (Wightman et al., 2020).
Enhanced Mental Performance: Research shows Zynamite (Siagalore™) effectively enhances cognitive function through randomized, double-blind, placebo-controlled trials (Jayakodi et al., 2024).
Synergistic Action: Studies confirm that Mangifera indica leaf extract acts synergistically with caffeine to modulate electrophysiological parameters of the rat central nervous system (Dimpfel et al., 2018).
Neuroprotective Properties: Mangiferin demonstrates therapeutic potential in managing cognitive decline associated with neuropsychiatric and neurodegenerative disorders (Walia et al., 2021).
Lifestyle Disease Protection: Research indicates mangiferin acts as a natural miracle bioactive compound effective against lifestyle-related health concerns (Imran et al., 2017).
Superior Bioavailability: Nanoparticle-loaded, fast-dissolving films containing Zynamite demonstrate significantly augmented paroxetine bioavailability (Elsebaey et al., 2021).
Key Benefits Validated by Research:
- Improved reaction time and accuracy in cognitive tasks
- Enhanced mental stamina during prolonged focus sessions
- Natural polyphenol-rich formula with antioxidant benefits
- Caffeine-free focus without jitters or dependency
Science-Led Approach
WIZBE Genius Strips are formulated based on cutting-edge nootropic research. Our ultra-thin dissolvable format maximizes bioavailability and absorption speed compared to traditional pill formulations. Each strip contains clinically-studied ingredients designed to support focus, mental clarity, and cognitive performance.
Quality Standards
Every batch is manufactured in FDA-registered facilities following strict GMP guidelines. We maintain rigorous quality control at every step, from ingredient sourcing to final packaging.
Impact & Vision
We're building a community of high-performers who demand more from their cognitive support. Our vision is to make premium brain nutrition accessible to everyone.
Research Partnerships
Peer-Reviewed Studies
All key ingredients backed by published research in cognitive neuroscience journals
Independent Testing
Third-party lab verification ensures purity, potency, and safety standards
Continuous Innovation
We partner with leading universities to explore frontiers in brain performance
Meet the Founders
Piray Atsak, PhD, MSc
Co-founder & Chief Science Officer
Leading neuroscientist with 15+ years of research in cognitive performance and neural optimization.
Yigit Eygi, MA
Co-founder & Chief Design Officer
Design visionary transforming complex science into intuitive, beautiful consumer experiences.
Clinically Proven Results
Rigorous double-blind, placebo-controlled studies demonstrate significant cognitive improvements with mangiferin supplementation.
Data adapted from Ref. 10
Mangiferin Increases Cognition via Reducing Dopamine Breakdown
Research indicates that mangiferin enhances dopamine signaling in the brain by inhibiting Catechol-O-methyltransferase (COMT), an enzyme responsible for breaking down neurotransmitters such as dopamine and norepinephrine.
These neurotransmitters play a critical role in supporting attention, cognition, and memory. By suppressing COMT activity, mangiferin helps sustain higher levels of these key neurotransmitters, thereby promoting improved cognitive function.
Moreover, mangiferin can also offer neuroprotective effects by reducing oxidative stress.
Figure adapted from ref. 4
Instant Benefits of Mangiferin on Cognitive Performance After a Single Dose
A landmark double-blind, placebo-controlled crossover study involving 70 healthy adults (ages 18-45) demonstrated significant cognitive benefits from a single 300 mg dose of mango leaf extract standardized to >60% mangiferin (MNG). These improvements were observed within 30 minutes of consumption and lasted for at least five hours. Another clinical study of 16 subjects reported MNG promotes mental speed by about 10% within an hour of consumption.
Focused Attention
*
Sustained Attention
*
Long-term Memory
*
Mental Speed
*
Left three panels are adapted from ref. 2, right panel is adapted from ref. 4. *Statistically significant difference with respect to placebo (P <0.05)
Benefits of Mangiferin on Cognitive Performance After Only 7 Days of Use
Another double-blind, placebo-controlled clinical study involving 60 healthy adults found that daily supplementation with 300 mg of mango leaf extract (standardized to >60% MNG) for seven days led to a significant improvement in mental focus and speed, as well as working and long-term memory. Remarkably, this treatment increased ability to sustain attention on cognitive tasks by more than 35%.
* All improvements statistically significant
Figure adapted from ref. 5. *Statistically significant difference with respect to placebo (P <0.05)
Key Clinical Findings
Effects within 30 minutes
Rapid onset of cognitive benefits
5+ hours duration
Sustained cognitive enhancement
10% faster mental speed
Within one hour of consumption
37% better sustained attention
After just 7 days of use
32% improved long-term memory
Significant memory enhancement
Double-blind studies
Placebo-controlled validation
Scientific References
1. Kevin Mcpadden, You Now Have a Shorter Attention Span than a Goldfish, Time magazine, May 14, 2015
2. Alis Behavioral Health, 2024
3. https://time.com/3858309/average-human-attention-span-statisti cs-and-facts
4. Wightman EL, Jackson PA, Forster J, et al. Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study. Nutrients. 2020;12(8):2194.
5. Jayakodi S, Krishnakumar A, Dalal M, Shetty BS. Assessment of Efficacy and Safety of Mangifera indica Extract (Stadice®) for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Study. Cureus. 2024 Jul 30;16(7):e65751.
6. Dimpfel W, Wiebe J, Dimpfel JW, Montales T, Gericke N. Effects of the central nervous system activity of extract Mangifera indica L. J Ethnopharmacol. 2020;250:112996.
7. Dimpfel W, Gericke N, Wiebe J, Schombert L, Murillo Gómez T. Mangifera indica Leaf Extract and Caffeine Act in a Synergistic Manner on Electrophysiological Parameters of Rat Central Nervous System. Food and Nutrition Sciences 2018, 09: 1563-1583.
8. Walia V, Chaudhary SK, Kohrar Sethiya N. Therapeutic potential of mangiferin in the treatment of various neuropsychiatric and neurodegenerative disorders. Neurochem Int. 2021 Feb;143:104949.
9. Imran M, Arshad MU, Butt MS, Kwon JH, Arshad MU, Sultan MT. Mangiferin: a natural miracle bioactive compound against lifestyle related disorders. Lipids Health Dis. 2017 May 19;16(1):84.
10. Castellote-Caballero Y, Beltrán-Arranz A, Aibar-Almazán A, Carcelén-Fraile MDC, Rivas-Campo Y, López-Ríos L, Vega-Morales T, González-Martín AM. Acute Supplementation of Soluble Mango Leaf Extract (Zynamite®️ S) Improves Mental Performance and Mood: A Randomized, Double-Blind, Placebo-Controlled Crossover Study. Pharmaceuticals (Basel). 2025 Apr 14;18(4):571. doi: 10.3390/ph18040571. PMID: 40284006; PMCID: PMC12030201.
11. Elsafeey, Ahmed Hassen, and Rania Moataz ElShaer. "Formulation and Development of Nanoparticle-Loaded with Nanosuspension to Augment Paroxetine Bioavailability: In Vitro Characterization, Ex Vivo Permeation, and Pharmacokinetic Evaluation in Healthy Human Volunteers." Pharmaceutics vol. 13,11 1869. 5 Nov. 2021